Lecture Notes

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This page presents the lecture notes for each class session, plus supporting multimedia for some sessions.

1 Introduction to nanomechanics (PDF) Amazon logo Feynman, Richard. Tiny Machines. Audio CD, Sound Photosynthesis, 1984.
2 High resolution force spectroscopy (HRFS): The force transducer (PDF)
3 Additional nanomechanics instrumentation components (PDF)
4 Force versus distance curves (PDF)
5 Atomic force microscope (AFM) imaging (PDF)

Video: "Understanding AFM"
(RM - 56K) (RM - 220K) (MOV - 111.5MB)
(Courtesy of Asylum Research, Inc. Used with permission)

Force curve animation, from NC State University (MOV)

6 AFM imaging II: Artifacts and applications (PDF)
7 Single cell mechanics (PDF)
8 Qualitative Introduction to intra- and intermolecular forces (PDF) Protein Folding demo [You will need the MDL Chime plugin for your browser, which is a free download.]
9 Quantitative description of intra- and intermolecular forces (PDF)
10 Molecule-surface interactions (PDF)
11 Colloids and interparticle potentials (PDF)
12 Van der Waals forces at work: Gecko feet adhesion (PDF)
13 Midterm exam solutions review (PDF)
14 The electrical double layer (EDL) - part 1 (PDF)
15 The electrical double layer (EDL) - part 2 (PDF)
16 Nanomechanics of cartilage (PDF - 2.0 MB)
17 Protein-surface interactions (PDF - 1.3 MB)

Polymer Brush simulation. John Marko, Cornell University, 1994.

Simulation of Polymer Brush Interacting with Nanosized Object (AVI) (Courtesy of Jan Hoh. Used with permission.)

18 Nanomechanics and biocompatibility: Protein-biomaterial interactions, part 2 (PDF) Same as prior session.
19 Elasticity of single polymer chains: Theoretical formulations (PDF)
20 Theoretical aspects of single molecule force spectroscopy: Extensibility and the worm-like chain (WLC) (PDF)
21 Single chain elasticity of biomacromolecules: The giant protein titin and DNA (PDF)

From the Theoretical and Computational Physics Group, UIUC:

Movie of SMFS Fibronectin stretching (MPEG - 1.7 MB)

Simulations of unfolding titin immunoglobulin domains

22 Theoretical aspects of nanoindentation (PDF)
23 Nanoindentation 2: Oliver-Pharr method and one literature example: Nacre (PDF - 1.0 MB)
24 Intermolecular interactions in motility of a biological spring (guest lecture by Danielle France, course TA)