Lecture Notes

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Several lectures are given by the course TA Dr. Ikuo Taniguchi.


Lec # TOPICS
1 Course Introduction (PDF)

Biomaterials Defined

Structural Hierarchy in Materials and Biology
2 Biomaterials Surfaces: Physics (PDF)

Surface (vs. Bulk) Structure and Properties

Surface Energy

Adsorption, Segregation, and Reconstruction at Surfaces
3 Biomaterials Surfaces: Chemistry (PDF)

Reactions at Surfaces: Chemisorption, Corrosion
4 Biomaterials Surfaces: Chemistry (cont.) (PDF)

Hydrolysis (Dr. Taniguchi) (PDF - 1.3 MB)
5 Protein-Surface Interactions (PDF)#

Proteins: Structure, Properties, Functions

Protein Adsorption: Langmuir Model
6 Protein-Surface Interactions (cont.) (PDF)

Protein Adbsorption: Complex Phenomena, Measurement
7 Cell-Surface Interactions: Host Response to Biomaterials (PDF - 1.3 MB)

Cell Adhesion Mechanisms

Coagulation Cascade
8 Cell-Surface Interactions: Host Response to Biomaterials (cont.) (PDF)

Immune Response: Alternative Complement Activation
9 Surface Modification Methods (PDF)

Purposes

Plasma Treatments

Organic Coatings (Dr. Taniguchi) (PDF)
10 Surface Modification Methods (cont.) (PDF)

Polymer Coatings

Patterned Surfaces
11 Surface Characterization (PDF)

In Vacuum: XPS/ESCA, AES, SIMS
12 Surface Characterization In situ (PDF)#

Contact Angle, AFM
13 Quantifying Cell Behavior (PDF)

Cell Cultures

Cellular Assays: Adhesion, Migration, Proliferation
14 Quantifying Cell Behavior (cont.) (PDF)

Cellular Assays: Differentiation, Function
15 Statistical Analysis (PDF)

Error Sources, Distribution Functions, t- test
16 Statistical Analysis (cont.) (PDF)

Fisher Test, Regression Methods
17 Biosensors and Diagnostic Devices (PDF)

Biological Elements

Transduction Mechanisms

Properties

Examples: Fiber Optic Biosensors, Nanobarcodes
18 Drug Delivery: Controlled Release (Dr. Taniguchi) (PDF)

Chemically-controlled Devices
19 Drug Delivery: Controlled Release (cont.) (PDF)

Diffusion-controlled, Membrane-based and Osmotic Devices
20 Drug Delivery: Controlled Release (cont.) (PDF)

Methods: Transdermal, Colloidal Vehicles

Mechanical Pumps
21 Biomaterials for Organ Replacement (PDF)

Organ Replacement Therapies

Mechanical Properties

Bone Substitutes
22 Tissue Engineering (PDF)

Cell Types

Approaches: In vitro, In vivo, Ex vivo/Cell Encapsulation

Scaffolds: Design and Fabrication
23 Tissue Engineering (cont.) (PDF)

Case Examples: Artificial Pancreas, Cartilage, Nerve Regeneration
24 FDA Regulatory Issues and Course Evaluations (PDF)