HST.583 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis

Fall 2008

fMRI images and bar charts comparing responses to verum and sham acupuncture treatments.

A recently published study conducted by some HST.583 instructors used fMRI to assess the brain basis of pain relief underlying acupuncture and expectancy-evoked placebo treatments. (Source: Kong, J., T. J. Kaptchuk, G. Polich, I. Kirsch, M. Vangel, C. Zyloney, B. Rosen, and R. Gollub. "Expectancy and treatment interactions: A dissociation between acupuncture analgesia and expectancy evoked placebo analgesia." NeuroImage 45, no. 3 (15 April 2009): 940-949. doi:10.1016/j.neuroimage.2008.12.025. Courtesy of Elsevier, Inc., http://www.sciencedirect.com . Used with permission.)

Course Description

This team-taught multidisciplinary course provides information relevant to the conduct and interpretation of human brain mapping studies. It begins with in-depth coverage of the physics of image formation, mechanisms of image contrast, and the physiological basis for image signals. Parenchymal and cerebrovascular neuroanatomy and application of sophisticated structural analysis algorithms for segmentation and registration of functional data are discussed. Additional topics include: fMRI experimental design including block design, event related and exploratory data analysis methods, and building and applying statistical models for fMRI data; and human subject issues including informed consent, institutional review board requirements and safety in the high field environment.

Technical Requirements

Special software is required to use some of the files in this course: .dcm, .mnc, .mov and .zip.

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Course Director:
Dr. Randy Gollub

Div Bolar
Dr. Bradford Dickerson
Dr. John Gabrieli
Dr. Doug Greve
Dr. Karl Helmer
Dr. Dara Manoach
Dr. Jason Mitchell
Dr. Christopher Moore
Dr. Vitaly Napadow
Dr. Jon Polimeni
Dr. Sonia Pujol
Dr. Bruce Rosen
Dr. Mert Sabuncu
Dr. David Salat
Dr. Robert Savoy
Dr. David Somers
Dr. A. Gregory Sorensen
Dr. Christina Triantafyllou
Dr. Wim Vanduffel
Dr. Mark Vangel
Dr. Lawrence Wald
Dr. Susan Whitfield-Gabrieli
Dr. Anastasia Yendiki

Course Meeting Times

2 sessions / week
1 hour / session

1 session / week
1.5 hours / session

1 session / week
1 hour / session



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