HST.512 Genomic Medicine

Spring 2004

Illustration showing basic steps used in microarray technology.
Illustration showing basic steps used in microarray technology. (Figure by OCW.)

Course Highlights

Audio of most lecture sessions, in addition to downloadable lecture notes, are available for this course.

Course Description

This course reviews the key genomic technologies and computational approaches that are driving advances in prognostics, diagnostics, and treatment. Throughout the semester, emphasis will return to issues surrounding the context of genomics in medicine including: what does a physician need to know? what sorts of questions will s/he likely encounter from patients? how should s/he respond? Lecturers will guide the student through real world patient-doctor interactions. Outcome considerations and socioeconomic implications of personalized medicine are also discussed. The first part of the course introduces key basic concepts of molecular biology, computational biology, and genomics. Continuing in the informatics applications portion of the course, lecturers begin each lecture block with a scenario, in order to set the stage and engage the student by showing: why is this important to know? how will the information presented be brought to bear on medical practice? The final section presents the ethical, legal, and social issues surrounding genomic medicine. A vision of how genomic medicine relates to preventative care and public health is presented in a discussion forum with the students where the following questions are explored: what is your level of preparedness now? what challenges must be met by the healthcare industry to get to where it needs to be?

Special Features

Technical Requirements

RealOne™ Player software is required to run the .rm files found on this course site.

RealOne™ is a trademark or a registered trademark of RealNetworks, Inc. 

Donate Now


Prof. Isaac Samuel Kohane
Dr. Atul J. Butte
Dr. Steven A. Greenberg
Dr. Alvin Thong-Juak Kho
Dr. Peter Park
Dr. Marco F. Ramoni
Dr. Alberto A. Riva
Dr. Zoltan Szallasi

Guest Lecturers:
Dr. Jeffrey Mark Drazen
Dr. Todd Golub
Dr. Joel Hirschhorn
Dr. Greg Tucker-Kellogg
Dr. Scott Weiss

Course Meeting Times

Two sessions / week
1.5 hours / session