Readings

Amazon logo When you click the Amazon logo to the left of any citation and purchase the book (or other media) from Amazon.com, MIT OpenCourseWare will receive up to 10% of this purchase and any other purchases you make during that visit. This will not increase the cost of your purchase. Links provided are to the US Amazon site, but you can also support OCW through Amazon sites in other regions. Learn more.

Recommended Texts and Articles

Amazon logo Hartl, Daniel L.A Primer of Population Genetics. 3rd ed. Sunderland, MA: Sinauer Associates, 2000. ISBN: 9780878933044.

Amazon logo Watson, James D., Tania Baker, Stephen Bell, Alexander Gann, Michael Levine, and Richard Losick. Molecular Biology of the Gene. 5th ed. San Francisco, CA: Pearson/Benjamin Cummings, 2003. ISBN: 9780805346350.

Amazon logo Strachan, Tom, and Andrew P. Read. Human Molecular Genetics. 2nd ed. New York, NY: Wiley, 1999. ISBN: 9780471330615.

Amazon logo Koonin, Eugene V. Galperin, and Michael Y. Norwell. Sequence - Evolution - Function: Computational Approaches in Comparative Genomics. New York, NY: Springer, 2002. ISBN: 9781402072741.

Amazon logo Li, Wen-Hsiung.Molecular Evolution. Sunderland, MA: Sinauer Associates, 1997. ISBN: 9780878934638.

Amazon logo Rice, Sean H.Evolutionary Theory: Mathematical and Conceptual Foundations. Sunderland, MA: Sinauer Associates, 2004. ISBN: 9780878937028.

Amazon logo Felsenstein, Joseph.Inferring Phylogenies. Sunderland, MA: Sinauer Associates, 2003. ISBN: 9780878931774.

Amazon logo Gillespie, John H.Population Genetics: A Concise Guide. 2nd ed. Baltimore, MD: Johns Hopkins University Press, 2004. ISBN: 9780801880094.

Kreitman, Martin. "Methods to Detect Selection in Populations With Applications to the Human." Annu Rev Genomics Hum Genet 01 (2000): 539-59.

Suggested Papers

Gould, Stephen Jay, and Richard C. Lewontin. "The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist P." Proc Roy Soc London B 205 (1979): 581-598.

Prediction of Protein Function

Korbel, J. O., L. J. Jensen, Mering C. Von, and P. Bork. "Analysis of genomic context: Prediction of functional associations from conserved bidirect." Nat Biotechnol 22, no. 7 (July 2004): 911-7.

Pellegrini, M., E. M. Marcotte, M. J. Thompson, D. Eisenberg, and T. O. Yeates. "Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles." Proc Natl Acad Sci U.S.A. 96, no. 8 (April 13, 1999): 4285-8.

Sonnhammer, E. L., S. R. Eddy, E. Birney, A. Bateman, and R. Durbin. "Pfam: Multiple sequence alignments and HMM-profiles of protein domains." Nucleic Acids Res 26, no. 1 (January 1, 1998): 320-2.

Medical Lecture 2 (Dr. Marco Ramoni)

Hoh, J., and J. Ott. "Mathematical multi-locus approaches to localizing complex human trait genes." Nat Rev Genet 4, no. 9 (September 2003): 701-9.

Sebastiani, P., M. F. Ramoni, V. Nolan, C. T. Baldwin, and M. H. Steinberg. "Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia." Nat Genet 37, no. 4 (April 2005): 435-40.

Module 4: Functional Genomics

Turing, A. M. "The Chemical Basis of Morphogenesis Philosophical Transactions of the Royal Society of London." Series B, Biological Sciences 237, no. 641 (August 14, 1952): 37-72.

Online Resources

A Population Genetics Primer Online

Pfam Database