5.451 Chemistry of Biomolecules I

Fall 2005

Crystal structure of shikimate kinase.
Crystal structure of shikimate kinase. (Image courtesy of the RCSB PDB. PDB ID: 1VIA. Badger, J., et al. "Structural analysis of a set of proteins resulting from a bacterial genomics project." Proteins 60 (2005): 787-796.)

Course Highlights

This course features a full set of problem sets with solutions in the assignments section.

Course Description

5.451 is a half-semester introduction to natural product biosynthetic pathways. The course covers the assembly of complex polyketide, peptide, terpene and alkaloid structures. Discussion topics include chemical and biochemical strategies used to elucidate natural product pathways.
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Prof. Sarah O'Connor

Course Meeting Times

Two sessions / week
1.5 hours / session