5.069 Crystal Structure Analysis

Spring 2008

Molecular model of amino acid tyrosine overlaid on photograph of xray diffractometer.
Molecular model of the amino acid tyrosine with experimental electron density in front of an X-ray diffractometer at MIT. The tyrosine is part of the crystal structure of phosphoglycerate mutase from M. tuberculosis. See Mueller, P., et al. Acta Cryst D61 (2005): 309-315. (Figure and photograph by Dr. Peter Mueller.)

Course Description

This course covers the following topics: X-ray diffraction: symmetry, space groups, geometry of diffraction, structure factors, phase problem, direct methods, Patterson methods, electron density maps, structure refinement, how to grow good crystals, powder methods, limits of X-ray diffraction methods, and structure data bases.

*Some translations represent previous versions of courses.

Donate Now


Dr. Peter Mueller

Course Meeting Times

18 sessions over 7 weeks
1 hour / session




Archived Courses

Previous version