10.492-2 Integrated Chemical Engineering Topics I: Introduction to Biocatalysis

Fall 2004

Structural image of protein strucure from PDB database.
The Crystal Structure Of Bacillus Subtilis Lipase: A Minimal a/b Hydrolase Enzyme. PDB ID: 1I6W. van Pouderoyen, G., T. Eggert, K. E. Jaeger, B. W. Dijkstra: The crystal structure of Bacillus subtilis lipase: a minimal alpha/beta hydrolase fold enzyme. J. Mol. Biol. 309, issue 1 (May 25, 2001): 215-26. (Image courtesy of the Research Collaboratory for Structural Bioinformatics. Berman, H. M., J. Westbrook, Z. Feng, G. Gilliland, T. N. Bhat, H. Weissig, I. N. Shindyalov, and P. E. Bourne. "The Protein Data Bank." Nucleic Acids Research 28 (2000): 235-242.)

Course Highlights

This course includes a selection of downloadable lecture notes.

Course Description

This course provides a brief introduction to the field of biocatalysis in the context of process design. Fundamental topics include why and when one may choose to use biological systems for chemical conversion, considerations for using free enzymes versus whole cells, and issues related to design and development of bioconversion processes. Biological and engineering problems are discussed as well as how one may arrive at both biological and engineering solutions.

*Some translations represent previous versions of courses.

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Prof. Kristala L. Jones Prather

Course Meeting Times

Eighteen sessions for 5 weeks
1 hour / session