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The textbook used in this course is Branden and Tooze:

Amazon logo Branden, Carl, and John Tooze. Introduction to Protein Structure. 2nd ed. New York, NY: Garland Science, 1999. ISBN: 9780815323051.

Ribonuclease References

Refolding of Denatured RNAse In Vitro

Sela, M., F. H. White Jr., and C. B. Anfinsen. "Reductive Cleavage of Disulfide Bridges in Ribonuclease." Science 125 (1957): 691-692.

White, Frederick H. "Regeneration of Native Secondary and Tertiary Structures by Air Oxidation of Reduced Ribonuclease." J Biol Chem 236 (1961): 1353-1360.

Anfinsen, C. B., and Edgar Haber. "Studies on the Reduction and Re-formation of Protein Disulfide Bonds." J Biol Chem 236 (1960): 1361-1363.

Anfinsen, C. B., Edgar Haber, M. Sela, and F. H. White, Jr. "The Kinetics of Formation of Native Ribonuculease During Oxidation of the Reduced Polypeptide Chain." PNAS 47 (1961): 1309-1314.

Nobel Lectures

Anfinsen, C. B. "Principles that Govern the Folding of Protein Chains." Science 181 (1973): 223-230.

Moore, S., and W. H. Stein. "Chemical Structures of Pancreatic Ribonuclease and Deoxyribonuclease." Science 180 (1973): 458-464.

Folding of Coiled Coils References

Hodges, R. S., J. Sodex, L. B. Smillie, and L. Jurasek. "Tropomyosin: Amino Acid Sequence and Coiled-coil Structure.

Lehrer, Sherwin S., and Amy Yuan. "The Stability of Tropomyosin at Acid pH: Effects of Anion Binding." J Structural Biology 122 (1998): 176-179.

Lehrer, Sherwin S., Yude Qian, and Soren Hvidt. "Assembly of the Native heterodimer of Rana Esculenta Tropomyosin by Chain Exchange." Science 246 (1989): 926-928.

Suarez, Marisa C., Sherwin S. Lehrer, and Jerson L. Silva. "Local Heterogeneity in the Pressure Denaturation of the Coiled-coil Tropomyosin because of Subdomain Folding Units." Biochemistry 40 (2001): 1300-1307.

Rasmussen, Randy, Dominic Benvegnu, Erin K. O'Shea, Peter S. Kim, and Tom Alber. "X-ray Scattering Indicates that the Leucine Zipper is a Coiled Coil." PNAS 88 (1991): 561-564.

Cohen, Carolyn, and David A. D. Parry. "Alpha-Helical Coiled Coils and Bundles: How to Design an Alpha-helical Protein." Proteins 7 (1990): 1-15.

O'Shea, Erin K., Juli D. Klemm, Peter S. Kim, and Tom Alber. "X-ray Structure of the GCN4 Leucine Zipper, a Two-stranded, Parallel Coiled Coil." Science 254 (1991): 539-544.

Harbury, Pehr B., Tao Zhang, Peter S. Kim, and Tom Alber. "A Switch Between two-, three- and four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants." Science 262 (1993): 1401-1407.

NMR Refolding of Cytochrome C Reference

Roder, H., G. A. Elove, S. W. Englander. "Structural Characterization of Folding Intermediates in Cytochrome c by H-exchange Labeling and Proton NMR." Nature 335 (1988): 700-704.

Collagen Conformation and Chain Folding References

Structure and Stability

Rich, Alexander, and Francis H. C. Crick. "The Molecular Structure of Collagen." J Mol Biol 3 (1961): 483-506.

Josse, John, and William F. Harrington. "Role of Pyrrolidine Residues in the Structure and Stabilization of Collagen." J Mol Biol 9 (1964): 269-287.

Harrington, W. F. "On the Arrangement of the Hydrogen Bonds in the Structure of Collagen." J Mol Biol 9 (1964): 613-617.

Segal, D. M. "Polymers of Tripeptides as Collagen Models VII. Synthesis and Solution Properties of Four Collagen-like Polyhexapeptides." J Mol Biol 43 (1969): 497-517.

Harrington, F., and N. V. Rao. "Collagen Structure in Solution I. Kinetics of Helix Regeneration in Single Chain Gelatins." Biochem 9 (1970): 3712-3724.
(See also the papers II-V which follow the above in the Journal.)

Bella, J., M. Eaton, B. Brodsky, and H. M. Berman. "Crystal and Molecular Structure of a Collagen-like Peptide at 1.9Å Resolution." Science 266 (1994): 75-81.

Biosynthesis and In Vivo Maturation

Prockop, D. J., et al. "The Biosynthesis of Collagen and its Disorders. (First of Two Parts)." New England Journal of Medicine 301, no. 1 (1979): 13-23.

———. "The Biosynthesis of Collagen and its Disorders. (Second of Two Parts)." New England Journal of Medicine 301, no. 2 (1979): 77-85.

Fessler, Liselotte J., and John H. Fessler. "Characterization of Type III Procollagen from Chick Embryo Blood Vessels." J Biol Chem 254 (1981): 233-239.

Bachinger. B., et al. "Chain Assembly Intermediate in the Biosynthesis of Type III\j\Procollagen in Chick Embryo Blood Vessels." J Biol Chem 256 (1981): 13193-13199.

Steinmann, et al. "Cysteine in the Triple-helical Domain of One Allelic Product of the pro-alpha1(I) Gene of Type I Collagen Produces a Lethal Form of Osteogenesis Imperfecta." J Biol Chem 259 (1984): 11129-11138.

Bonadio, et al. "Altered Triple Helical Structure of Type I Procollagen in Lethal Perinatal Osteogenesis Imperfecta." J Biol Chem 260 (1985): 1734-1742.

Bonadio, and P. Byers. "Subtle Structural Alterations in the Chains of Type I Procollagen Produce Osteogenesis Imperfecta Type II." Nature 316 (1985): 363-365.

Baldwin, C. T., C. D. Constantantinou, K. W. Dumars, and Darwin J. Prockop. "A Single Base Mutation that Converts Glycine 907 of the Alpha2(I) Chain of Type I Procollagen to Aspartate in a Lethal Variant of Osteogenesis Imperfecta." J Biol Chem 264 (1989): 3002-3006.


Engel, Jurgen, and Darwin J. Prockop. "The Zipper-like Folding of Collagen Triple Helices and the Effects of Mutations that Disrupt the Zipper." Ann Rev Biophys Biophys Chem 20 (1991): 137-152.

Van der Rest, M., and R. Garrone. "Collagens as Multidomain Proteins." Biochimie 72 (1990): 473-484.

Byers, Peter H., Gillian A. Wallis, and Marcia C. Willing. "Osteogenesis Imperfecta: Translation of Mutation to Phenotype." J Medical Genetics 28 (1991): 433-442.

Kuvaniemi, Helena, Gerard Tromp, and Darwin J. Prockop. "Mutations in Collagen Genes: Causes of Rare and Some Common Diseases in Humans." FASEB J 5: 2052-2060.

Baum, J., and B. Brodsky. "Real Time NMR Investigations of Triple Helix Folding and Collagen Folding Diseases." Fold Des 2 (1997): R53-R60.