20.482J / 6.581J Foundations of Algorithms and Computational Techniques in Systems Biology

Spring 2006

Predicted 3-D structure of the Rad checkpoint complex.
The role of the Rad checkpoint complex was inferred from the 3-D structure predicted by comparative modeling at Lawrence Livermore National Laboratory. The Rad complex delays cell division to allow time for DNA repair to take place. (Image courtesy of the U.S. Department of Energy Genomics: GTL Program.)

Course Highlights

This course features a complete set of lecture notes and assignments.

Course Description

This subject describes and illustrates computational approaches to solving problems in systems biology. A series of case-studies will be explored that demonstrate how an effective match between the statement of a biological problem and the selection of an appropriate algorithm or computational technique can lead to fundamental advances. The subject will cover several discrete and numerical algorithms used in simulation, feature extraction, and optimization for molecular, network, and systems models in biology.

Technical Requirements

Special software is required to use some of the files in this course: .zip, .dat, .m, .qif, and .bmp.

Donate Now


Prof. Bruce Tidor
Prof. Jacob White

Course Meeting Times

Two sessions / week
1.5 hours / session