20.201 Mechanisms of Drug Actions

Fall 2005

Pharmacogenetic determinants of the metabolism and anti-ulcer activity of omeprazole.
Three sets of brain scans from a young adult given a placebo (top) and two different doses of methylphenidate (bottom), showing the ability of methylphenidate to block the transporter "gates" by which the brain chemical dopamine returns to its home cell after sending a pleasure signal. (Image courtesy of the Brookhaven National Laboratory.)

Course Highlights

This course features a complete set of assignments.

Course Description

This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered.

Special Features

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Prof. Peter Dedon
Prof. Steven Tannenbaum

Course Meeting Times

Two sessions / week
1.5 hours / session

One session / week
1 hour / session